Article
HapMap-based study of a region encompassing ERCC1 and ERCC2 related to lung cancer susceptibility in a Chinese population.
Mutation research - 1 Aug 2011
Yin Jiaoyang, Vogel Ulla, Ma Yegang, Qi Rong, Wang Huiwen, Yue Li, Liang Duohong, Wang Chunhong, Li Xinxin, Song Tiehua
Abstract excerpt
DNA repair genes play a crucial role in carcinogenesis. The paper aims to explore if common variants in ERCC1 are involved in lung cancer susceptibility. A Chinese case-control study included 339 lung cancer cases and 358 controls using five haplotype-tagging SNPs (htSNPs) (rs3212980, rs3212964, rs3212961, rs11615 and rs2298881) from the HapMap database, capturing 95% of the common haplotypic diversity of ERCC1....