Article
Tagging single nucleotide polymorphisms in excision repair cross-complementing group 1 (ERCC1) and risk of primary lung cancer in a Chinese population.
Pharmacogenetics and genomics - 1 Jun 2007
Ma Hongxia, Xu Liang, Yuan Jing, Shao Minhua, Hu Zhibin, Wang Feng, Wang Yi, Yuan Wentao, Qian Ji, Wang Ying, Xun Pengcheng, Liu Hongliang, Chen Weihong, Yang Lin, Jin Guangfu, Huo Xiang, Chen Feng, Shugart Yin Yao, Jin Li, Wei Qingyi, Wu Tangchun, Shen Hongbing, Huang Wei, Lu Daru
Abstract excerpt
BACKGROUND AND OBJECTIVE: Low nucleotide excision repair (NER) capacity has been associated with increased risk of lung cancer. Excision repair cross-complementing group 1 (ERCC1) is one of the NER core enzymes, and polymorphisms in ERCC1 may lead to altered repair function of the enzyme and therefore confer predisposition to cancer. The goal of this study was to test the hypothesis that common variants in ERCC1...
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