Article
Differential angiogenesis function of CCM2 and CCM3 in cerebral cavernous malformations.
Neurosurgical focus - 1 Sept 2010
Zhu Yuan, Wu Qun, Xu Jin-Fang, Miller Dorothea, Sandalcioglu I Erol, Zhang Jian-Min, Sure Ulrich
Abstract excerpt
OBJECT: Loss-of-function mutations in CCM genes are frequently detected in familial cerebral cavernous malformations (CCMs). However, the current functional studies of the CCM genes in vitro have been performed mostly in commercially purchased normal cell lines and the results appeared discrepant...
Topics
- Adult
- Apoptosis Regulatory Proteins
- Carrier Proteins
- Endothelial Cells
- Female
- Gene Silencing
- Hemangioma, Cavernous, Central Nervous System
- Humans
- Male
- Membrane Proteins
- Models, Genetic
- Mutation
- Neovascularization, Pathologic
- Proto-Oncogene Proteins
- RNA, Small Interfering
- Signal Transduction