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Article

Differential angiogenesis function of CCM2 and CCM3 in cerebral cavernous malformations.

Neurosurgical focus - 1 Sept 2010

Zhu Yuan, Wu Qun, Xu Jin-Fang, Miller Dorothea, Sandalcioglu I Erol, Zhang Jian-Min, Sure Ulrich

Abstract excerpt

OBJECT: Loss-of-function mutations in CCM genes are frequently detected in familial cerebral cavernous malformations (CCMs). However, the current functional studies of the CCM genes in vitro have been performed mostly in commercially purchased normal cell lines and the results appeared discrepant. The fact that the cerebral vascular defects are rarely observed in CCM gene-deficient animals suggests the...

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Source

Identifiers

PMID: 20809750
DOI: 10.3171/2010.5.FOCUS1090

Genes

CCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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