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Plasma pTau-181 Exhibits Flat Longitudinal Trajectories and Weak Cognitive Correlation in UK Biobank: Implications for Anti-Tau Antibody Trial Failures

2025-12-01

Abstract excerpt

<title>Abstract</title> <p>Background Monoclonal antibodies targeting pathological tau have repeatedly failed in Alzheimer’s disease (AD) clinical trials. Whether plasma phosphorylated tau (pTau) exhibits dynamic progression or cognitive relevance in population-based cohorts remains unclear. Methods Using UK Biobank, we analyzed 2,523 participants with plasma pTau-181 measured at imaging visits and stratified by...

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Literature Corpus work: ff038fc5-62ac-5bee-8b3c-454415aa0932
DOI: 10.21203/rs.3.rs-8204349/v1

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