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Article

Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon.

PLoS genetics - 16 Sept 2010

Van Otterloo Eric, Li Wei, Bonde Gregory, Day Kristopher M, Hsu Mei-Yu, Cornell Robert A

Abstract excerpt

A model of the gene-regulatory-network (GRN), governing growth, survival, and differentiation of melanocytes, has emerged from studies of mouse coat color mutants and melanoma cell lines. In this model, Transcription Factor Activator Protein 2 alpha (TFAP2A) contributes to melanocyte development by activating expression of the gene encoding the receptor tyrosine kinase Kit. Next, ligand-bound Kit stimulates a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20862309
DOI: 10.1371/journal.pgen.1001122
PMCID: PMC2940735

Genes

GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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