Transcriptomic analyses link changes in gene expression to defects in pigment cell differentiation and eye morphogenesis in a zebrafish model for Oculocutaneous Albinism Type 2.

doi:10.1016/j.ydbio.2026.07.011

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Article

Transcriptomic analyses link changes in gene expression to defects in pigment cell differentiation and eye morphogenesis in a zebrafish model for Oculocutaneous Albinism Type 2.

Developmental biology - 1 Nov 2026

Krilanovich Taylor M, McCarthy J Rionach, Vernon Samuel, Driskell Ryan, Cerveny Kara L, Cooper Cynthia D

Abstract excerpt

The oculocutaneous albinism 2 protein is required for melanin synthesis in vertebrates and its loss of function leads to one of the most common forms of skin and eye albinism, Oculocutaneous albinism (OCA). Using a zebrafish disease model for OCA2, we explore developmental explanations for pleiotropic traits observed in humans with OCA2. At multiple stages, we find that oca2 mutant zebrafish exhibit abnormal...

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Topics

Animals
Zebrafish
Albinism, Oculocutaneous
Cell Differentiation
Zebrafish Proteins
Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Gene Expression Profiling

Eye

Retinal Pigment Epithelium

Neural Crest

Disease Models, Animal

Morphogenesis

Transcriptome

Melanogenesis

Source

Open in PubMed

Identifiers

PMID: 42462946
DOI: 10.1016/j.ydbio.2026.07.011

Genes

OCA2
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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