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Article

AP-3 complex subunit delta gene, ap3d1, regulates melanogenesis and melanophore survival via autophagy in zebrafish (Danio rerio).

Pigment cell & melanoma research - 1 Sept 2022

Neuffer Sam J, Beltran-Cardona David, Jimenez-Perez Kevin, Clancey Lauren F, Brown Alexander, New Leslie, Cooper Cynthia D

Abstract excerpt

Zebrafish are an emerging model organism to study the syndromic albinism disorder, Hermansky-Pudlak syndrome (HPS), due to visible pigment development at 24 hours postfertilization, and conserved melanogenesis mechanisms. We describe crasher, a novel HPS type 10 (HPS10) zebrafish model, with a mutation in AP-3 complex subunit delta gene, ap3d1. Exon 14 of ap3d1 is overexpressed in crasher mutants, while the...

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Identifiers

PMID: 35816398
DOI: 10.1111/pcmr.13055
PMCID: PMC9450952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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