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Article

Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization.

Molecular immunology - 1 Feb 2009

Zhu Jianzhong, Brownlie Robert, Liu Qiang, Babiuk Lorne A, Potter Andrew, Mutwiri George K

Abstract excerpt

Toll-like receptors (TLRs) are a family of highly conserved germline-encoded pattern-recognition receptors (PRRs) and are essential for host immune response. Little is known regarding the activation mechanism of TLRs especially of the TLR7/8/9 subfamily. Here we cloned and characterized bovine TLR8 (bTLR8) and found that it is highly responsive to two TLR7 ligands, imiquimod and gardiquimod, in transfected cell...

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Source

Identifiers

PMID: 18995910
DOI: 10.1016/j.molimm.2008.09.024

Genes

TLR8
ECD
TLR7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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