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Host genetic variants in the IGF binding protein-3 impact on survival of patients with advanced gastric cancer treated with palliative chemotherapy.

Pharmacogenomics - 1 Sept 2010

Graziano Francesco, Ruzzo Annamaria, Canestrari Emanuele, Catalano Vincenzo, Santini Daniele, Galluccio Nadia, Loupakis Fotios, Alessandroni Paolo, Spada Daniele, Ficarelli Rita, Bisonni Renato, D'Emidio Silvia, Vincenzi Bruno, Angeletti Silvia, Salvatore Lisa, Cremolini Chiara, Tonini Giuseppe, Falcone Alfredo, Magnani Mauro

Abstract excerpt

AIM: IGF binding protein-3 (IGFBP-3) displays growth inhibitory/proapoptotic action and counteracts the IGF-1 tumor-promoting effects by downregulating its bioavailability. We investigated whether IGFBP-3 SNPs determining high IGFBP-3 circulating levels are associated with improved survival of pa...

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Source

Identifiers

PMID: 20860465
DOI: 10.2217/pgs.10.92

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20860465-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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