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Article

Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.

Gastroenterology - 1 Aug 2010

Dong Xiaoqun, Javle Milind, Hess Kenneth R, Shroff Rachna, Abbruzzese James L, Li Donghui

Abstract excerpt

BACKGROUND & AIMS: Insulin-like growth factor (IGF)-axis mediated signaling pathways play an important role in pancreatic cancer development and progression. We examined whether IGF-axis gene variants are associated with clinical outcomes in pancreatic cancer. METHODS: We retrospectively genotyped 41 single-nucleotide polymorphisms from 10 IGF-axis genes in 333 patients with localized pancreatic adenocarcinoma...

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Source

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Identifiers

PMID: 20416304
DOI: 10.1053/j.gastro.2010.04.042
PMCID: PMC2910789

Genes

IRS1
IGFBP3
IRS2
IGF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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