Article
A comprehensive analysis of the association of common variants of ABCG2 with gout.
Scientific reports - 30 Aug 2017
Yu Kuang-Hui, Chang Pi-Yueh, Chang Shih-Cheng, Wu-Chou Yah-Huei, Wu Li-An, Chen Ding-Pin, Lo Fu-Sung, Lu Jang-Jih
Abstract excerpt
The objective of the present study was to determine whether there was an association between single nucleotide polymorphisms (SNPs) in ABCG2 and gout. We recruited 333 participants including 210 patients with gout and 123 controls and genotyped 45 SNPs in both cohorts. We found that 24 SNPs in ABCG2 are susceptibility loci associated with gout. Haplotype analysis revealed five blocks across the ABCG2 locus were...
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