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Article

CYP2D6 polymorphism rs1065852 significantly increases the risk of type 2 diabetes.

Annals of medicine - 1 Dec 2025

Wei Huiyi, Zhao Qingbin

Abstract excerpt

BACKGROUND: Genetic variations within the cytochrome P450 (CYP) gene family are significant determinants of type 2 diabetes mellitus (T2DM) susceptibility. This study aimed to investigate the association between CYP2C8 and CYP2D6 gene variants and the risk of T2DM. METHODS: We conducted a case-control study involving 512 individuals with T2DM and 515 controls. Genotyping of CYP2C8 and CYP2D6 polymorphisms was...

Read the complete abstract on PubMed

Topics

Humans
Diabetes Mellitus, Type 2
Cytochrome P-450 CYP2D6
Male
Female
Middle Aged
Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Genetic Predisposition to Disease

Aged

Cytochrome P-450 CYP2C8

Genotype

Risk Factors

Adult

Aryl Hydrocarbon Hydroxylases

Multifactor Dimensionality Reduction

Source

Open in PubMed Open full text

Identifiers

PMID: 40028882
DOI: 10.1080/07853890.2025.2470956
PMCID: PMC11878161

Genes

CYP2C8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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