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Article

Homozygous inactivation of the LGI1 gene results in hypomyelination in the peripheral and central nervous systems.

Journal of neuroscience research - 15 Nov 2010

Silva Jeane, Sharma Suash, Hughes Bernard, Yu Y Eugene, Cowell John K

Abstract excerpt

Mutations in the LGI1 gene in humans predispose to the development of autosomal dominant partial epilepsy with auditory features (ADPEAF). Homozygous inactivation of the Lgi1 gene in mice results in an epilepsy phenotype characterized by clonic seizures within 2-3 weeks after birth. Before onset of seizures, the 2-3-week-old null mutant mice show poor locomotor activity and neuromuscular strength. EM analysis of...

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Source

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Identifiers

PMID: 20857514
DOI: 10.1002/jnr.22496
PMCID: PMC3885985

Genes

LGI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homozygous inactivation of the LGI1 gene results in hypomyelination in the peripheral and central nervous systems.PMID 20857514Read ↗

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