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Article

The claw paw mutation reveals a role for Lgi4 in peripheral nerve development.

Nature neuroscience - 1 Jan 2006

Bermingham John R, Shearin Harold, Pennington Jamie, O'Moore Jill, Jaegle Martine, Driegen Siska, van Zon Arend, Darbas Aysel, Ozkaynak Ekim, Ryu Elizabeth J, Milbrandt Jeffrey, Meijer Dies

Abstract excerpt

Peripheral nerve development results from multiple cellular interactions between axons, Schwann cells and the surrounding mesenchymal tissue. The delayed axonal sorting and hypomyelination throughout the peripheral nervous system of claw paw (clp) mutant mice suggest that the clp gene product is critical for these interactions. Here we identify the clp mutation as a 225-bp insertion in the Lgi4 gene. Lgi4 encodes...

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PMID: 16341215
DOI: 10.1038/nn1598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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