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Article

Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems.

PloS one - 15 Sept 2010

Bentley John P, Asselbergs Folkert W, Coffey Christopher S, Hebert Patricia R, Moore Jason H, Hillege Hans L, van Gilst Wiek H

Abstract excerpt

BACKGROUND: Vascular fibrinolytic balance is maintained primarily by interplay of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1). Previous research has shown that polymorphisms in genes from the renin-angiotensin (RA), bradykinin, and fibrinolytic systems affect plasma concentrations of both t-PA and PAI-1 through a set of gene-gene interactions. In the present study, we...

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Source

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Identifiers

PMID: 20856803
DOI: 10.1371/journal.pone.0012757
PMCID: PMC2939877

Genes

ACE
BDKRB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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