Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice.

Cardiovascular research - 1 Apr 2009

Abraham Theodore P, Jones Michelle, Kazmierczak Katarzyna, Liang Hsin-Yueh, Pinheiro Aurelio C, Wagg Cory S, Lopaschuk Gary D, Szczesna-Cordary Danuta

Abstract excerpt

AIMS: Several mutations in the ventricular myosin regulatory light chain (RLC) were identified to cause familial hypertrophic cardiomyopathy (FHC). Based on our previous cellular findings showing delayed calcium transients in electrically stimulated intact papillary muscle fibres from transgenic Tg-R58Q and Tg-N47K mice and, in addition, prolonged force transients in Tg-R58Q fibres, we hypothesized that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy, Hypertrophic, Familial
Share to Hemodynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocardial Contraction

Share to Myocardium

Share to Myofibrils

Share to Myosin Light Chains

Share to Sarcoplasmic Reticulum Calcium-Transporting ATPases

Share to Ventricular Dysfunction, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 19150977
DOI: 10.1093/cvr/cvp016
PMCID: PMC2721639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice.PMID 19150977Read ↗

Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations.Semantic proximity Read ↗

F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers.Semantic proximity Read ↗

Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.Semantic proximity Read ↗

Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics.Semantic proximity Read ↗

Independent FHC-related cardiac troponin T mutations exhibit specific alterations in myocellular contractility and calcium kinetics.Semantic proximity Read ↗

Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry.Semantic proximity Read ↗

The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice.Semantic proximity Read ↗

Cardiac contractility, motor function, and cross-bridge kinetics in N47K-RLC mutant mice.Semantic proximity Read ↗

Myosin regulatory light chain mutation found in hypertrophic cardiomyopathy patients increases isometric force production in transgenic mice.Semantic proximity Read ↗

Cardiac troponin T mutations: correlation between the type of mutation and the nature of myofilament dysfunction in transgenic mice.Semantic proximity Read ↗

HCM-linked ∆160E cardiac troponin T mutation causes unique progressive structural and molecular ventricular remodeling in transgenic mice.Semantic proximity Read ↗

Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.