Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Familial hypertrophic cardiomyopathy-linked alterations in Ca2+ binding of human cardiac myosin regulatory light chain affect cardiac muscle contraction.

The Journal of biological chemistry - 30 Jan 2004

Szczesna-Cordary Danuta, Guzman Georgianna, Ng Shuk-Shin, Zhao Jiaju

Abstract excerpt

The ventricular isoform of human cardiac regulatory light chain (HCRLC) has been shown to be one of the sarcomeric proteins associated with familial hypertrophic cardiomyopathy (FHC), an autosomal dominant disease characterized by left ventricular and/or septal hypertrophy, myofibrillar disarray, and sudden cardiac death. Our recent studies have demonstrated that the properties of isolated HCRLC could be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Calcium

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cardiomyopathy, Hypertrophic, Familial

Share to Circular Dichroism

Share to Electrophoresis, Polyacrylamide Gel

Share to Myocardial Contraction

Share to Myosin Light Chains

Share to Protein Isoforms

Source

Identifiers

PMID: 14594949
DOI: 10.1074/jbc.M307092200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Familial hypertrophic cardiomyopathy-linked alterations in Ca2+ binding of human cardiac myosin regulatory light chain affect cardiac muscle contraction.PMID 14594949Read ↗

Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry.Semantic proximity Read ↗

The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice.Semantic proximity Read ↗

Mechanical defects of muscle fibers with myosin light chain mutants that cause cardiomyopathy.Semantic proximity Read ↗

Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics.Semantic proximity Read ↗

Mutations in cardiac myosin heavy chain genes cause familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations.Semantic proximity Read ↗

Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle.Semantic proximity Read ↗

Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations.Semantic proximity Read ↗

Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation.Semantic proximity Read ↗

Myosin regulatory light chain mutation found in hypertrophic cardiomyopathy patients increases isometric force production in transgenic mice.Semantic proximity Read ↗

Predicting cardiomyopathic phenotypes by altering Ca2+ affinity of cardiac troponin C.Semantic proximity Read ↗

An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.