Article
Familial hypertrophic cardiomyopathy-linked alterations in Ca2+ binding of human cardiac myosin regulatory light chain affect cardiac muscle contraction.
The Journal of biological chemistry - 30 Jan 2004
Szczesna-Cordary Danuta, Guzman Georgianna, Ng Shuk-Shin, Zhao Jiaju
Abstract excerpt
The ventricular isoform of human cardiac regulatory light chain (HCRLC) has been shown to be one of the sarcomeric proteins associated with familial hypertrophic cardiomyopathy (FHC), an autosomal dominant disease characterized by left ventricular and/or septal hypertrophy, myofibrillar disarray, and sudden cardiac death. Our recent studies have demonstrated that the properties of isolated HCRLC could be...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Animals
- Binding Sites
- Calcium
- Cardiomyopathy, Hypertrophic, Familial
- Cells, Cultured
- Circular Dichroism
- DNA, Complementary
- Electrophoresis, Polyacrylamide Gel
- Humans
- Models, Biological
- Molecular Sequence Data