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Article

Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers.

The pharmacogenomics journal - 1 Oct 2015

Chua E W, Cree S, Barclay M L, Doudney K, Lehnert K, Aitchison A, Kennedy M A

Abstract excerpt

Preferential conversion of azathioprine or 6-mercaptopurine into methylated metabolites is a major cause of thiopurine resistance. To seek potentially Mendelian causes of thiopurine hypermethylation, we recruited 12 individuals who exhibited extreme therapeutic resistance while taking azathioprine or 6-mercaptopurine and performed whole-exome sequencing (WES) and copy-number variant analysis by array-based...

Read the complete abstract on PubMed

Topics

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Share to Azathioprine
Share to Colitis, Ulcerative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comparative Genomic Hybridization

Share to Crohn Disease

Share to Hepatitis, Autoimmune

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Share to Metabolic Networks and Pathways

Share to Methyltransferases

Source

Identifiers

PMID: 25752523
DOI: 10.1038/tpj.2015.9

Genes

ENOSF1
NFS1
RCC2

Provenance

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