Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment.

Blood - 1 Sept 2005

Zaza Gianluigi, Cheok Meyling, Yang Wenjian, Panetta John C, Pui Ching-Hon, Relling Mary V, Evans William E

Abstract excerpt

To elucidate interpatient variability in thioguanine nucleotide (TGN) concentrations in acute lymphoblastic leukemia (ALL) cells, we determined the TGN concentrations in leukemic blasts from 82 children with newly diagnosed ALL after intravenous administration of mercaptopurine (MP). Patients tre...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Dose-Response Relationship, Drug
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotides

Share to Mercaptopurine

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Thionucleotides

Share to Tissue Distribution

Source

Open in PubMed Open full text

Identifiers

PMID: 15905191
DOI: 10.1182/blood-2005-01-0143
PMCID: PMC1895216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15905191-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment.PMID 15905191Read ↗

Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy.Semantic proximity Read ↗

Effects of <i>NT5C2</i> germline variants on 6-mecaptopurine metabolism in children with acute lymphoblastic leukemiaSemantic proximity Read ↗

Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia.Semantic proximity Read ↗

Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamicsSemantic proximity Read ↗

Effects of NT5C2 Germline Variants on 6-Mecaptopurine Metabolism in Children With Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase statusSemantic proximity Read ↗

No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.Semantic proximity Read ↗

Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity.Semantic proximity Read ↗

Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemiaSemantic proximity Read ↗

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS.Semantic proximity Read ↗

Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesisSemantic proximity Read ↗

Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.