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Article

Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2005

Brouwer Connie, De Abreu Ronney A, Keizer-Garritsen Jenneke J, Lambooy Lambert H J, Ament Kai, ter Riet Patricia G J H, van Wering Elisabeth R, Trijbels Frans J M, Veerman Anjo J P, Hoogerbrugge Peter M, Bökkerink Jos P M

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme, catalysing S-methylation of aromatic and heterocyclic sulphhydryl compounds. TPMT activities and genotypes have been determined in patients with acute lymphoblastic leukaemia (ALL) and in control children. Median red blood cell (RBC) TPMT activity in ALL patients at diagnosis was significantly lower than in controls (median 11.5 pmol/10(7) RBC*hr; range...

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Identifiers

PMID: 15737567
DOI: 10.1016/j.ejca.2004.10.027

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects.PMID 15737567Read ↗

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