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Leishmania major: disruption of signal peptidase type I and its consequences on survival, growth and infectivity.

Experimental parasitology - 1 Oct 2010

Taheri Tahereh, Salmanian Ali-Hatef, Gholami Elham, Doustdari Fatemeh, Zahedifard Farnaz, Rafati Sima

Abstract excerpt

Leishmania major (L. major) signal peptidase type I (SPase I) is an endopeptidase encoded by a single-copy gene. In all organisms, SPase I is responsible for removing the signal peptide from secretory pre-proteins and releasing mature proteins to cellular or extra-cellular space. In this study, the role of SPase I in L. major is investigated by gene deletion using homologous recombination (HR). The null mutant of...

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PMID: 20417202
DOI: 10.1016/j.exppara.2010.04.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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