Article
No relationship between TNF-α genetic variants and combination antiretroviral therapy-related lipodystrophy syndrome in HIV type 1-infected patients: a case-control study and a meta-analysis.
AIDS research and human retroviruses - 1 Feb 2011
Veloso Sergi, Olona Montserrat, Peraire Joaquim, Viladés Consuelo, Pardo Pedro, Domingo Pere, Asensi Victor, Broch Montserrat, Aguilar Carmen, López-Dupla Miguel, Aragonés Gerard, Garcia-Pardo Graciano, Sirvent Joan-Josep, Vendrell Joan, Richart Cristóbal, Vidal Francesc
Abstract excerpt
Tumor necrosis factor alpha (TNF-α) is thought to be involved in the pathogenic and metabolic events associated with HIV-1 infection. We assessed whether carriage of the TNF-α gene promoter single nucleotide polymorphism (SNP) is associated with lipodystrophy and metabolic derangements in HIV-1-infected patients treated with cART. We also assessed variations in TNF-α receptor plasma levels. The study group...
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