Article
Analysis of a biallelic polymorphism in the tumor necrosis factor alpha promoter and HIV type 1 disease progression.
AIDS research and human retroviruses - 1 Mar 1998
Knuchel M C, Spira T J, Neumann A U, Xiao L, Rudolph D L, Phair J, Wolinsky S M, Koup R A, Cohen O J, Folks T M, Lal R B
Abstract excerpt
The relevance of a TNF-alpha promoter polymorphism, a G-to-A polymorphic sequence at position-308, was examined to test whether variant alleles of TNF-alpha affect susceptibility to infection with HIV-1 and progression to AIDS. Analysis of specimens from cohorts of HIV-1 positive homosexual men demonstrated that 3 of the 32 (9.4%) HIV-1-infected long-term nonprogressors (LTNPs) were homozygous for the uncommon...
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