Article
Polymorphisms of CXCR3-binding chemokines in type 1 diabetes.
Human immunology - 1 Jul 2009
Brück Patrick, Bartsch Wiebke, Penna-Martinez Marissa, Kahles Heinrich, Seidl Christian, Böhme Angelika, Badenhoop Klaus, Ramos-Lopez Elizabeth
Abstract excerpt
Type 1 diabetes (T1D) is a T-cell-mediated autoimmune disease. Although the precise mechanisms leading to the destruction of islet beta cells are unknown, diverse studies support a role of the CXCR3-binding chemokines. A combination of a case (n = 447)-control (n = 300) and family (n = 221) analysis was performed to investigate the role of the CXCL9 (rs10336, rs3733236) and CXCL10 (rs3921, rs35795399 and rs8878)...