Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.

The Journal of biological chemistry - 19 Nov 2010

Xiao Cuiying, Kim Hyun-Seok, Lahusen Tyler, Wang Rui-Hong, Xu Xiaoling, Gavrilova Oksana, Jou William, Gius David, Deng Chu-Xia

Abstract excerpt

Glucose homeostasis in mammals is mainly regulated by insulin signaling. It was previously shown that SIRT6 mutant mice die before 4 weeks of age, displaying profound abnormalities, including low insulin, hypoglycemia, and premature aging. To investigate mechanisms underlying the pleiotropic phenotypes associated with SIRT6 deficiency, we generated mice carrying targeted disruption of SIRT6. We found that 60% of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Lethal
Share to Glucose Transporter Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Transporter Type 2

Share to Hypoglycemia

Share to Immunoenzyme Techniques

Share to Muscle Fibers, Skeletal

Share to Sirtuins

Share to Tissue Distribution

Source

Open in PubMed Open full text

Identifiers

PMID: 20847051
DOI: 10.1074/jbc.M110.168039
PMCID: PMC2978606

Genes

SIRT6
IRS1
IRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.PMID 20847051Read ↗

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.Semantic proximity Read ↗

Characterization of physiological defects in adult SIRT6-/- mice.Semantic proximity Read ↗

Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.Semantic proximity Read ↗

SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan.Semantic proximity Read ↗

Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.Semantic proximity Read ↗

Temporal gating of SIRT1 functions by O-GlcNAcylation prevents hyperglycemia and enables physiological transitions in liverSemantic proximity Read ↗

Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.Semantic proximity Read ↗

In Search of New Therapeutic Targets in Obesity Treatment: Sirtuins.Semantic proximity Read ↗

Association of Genetic Variants of SIRT1 With Type 2 Diabetes Mellitus.Semantic proximity Read ↗

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.Semantic proximity Read ↗

SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and LipidsSemantic proximity Read ↗

SIRT1 transgenic mice show phenotypes resembling calorie restriction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.