Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT1 transgenic mice show phenotypes resembling calorie restriction.

Aging cell - 1 Dec 2007

Bordone Laura, Cohen Dena, Robinson Ashley, Motta Maria Carla, van Veen Ed, Czopik Agnieszka, Steele Andrew D, Crowe Hayley, Marmor Stephen, Luo Jianyuan, Gu Wei, Guarente Leonard

Abstract excerpt

We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the beta-actin locus. Mice that are hemizygous for this transgene express normal levels of beta-actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie-restricted diet: they are leaner than littermate controls; are more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines
Share to Blood Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caloric Restriction

Share to Cholesterol

Share to Insulin

Share to Longevity

Share to Sirtuin 1

Share to Sirtuins

Source

Identifiers

PMID: 17877786
DOI: 10.1111/j.1474-9726.2007.00335.x

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT1 transgenic mice show phenotypes resembling calorie restriction.PMID 17877786Read ↗

High calorie diet background alters the expression of sirtuins in the testes of mice under caloric restrictionSemantic proximity Read ↗

SIRT1: recent lessons from mouse modelsSemantic proximity Read ↗

Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.Semantic proximity Read ↗

SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan.Semantic proximity Read ↗

SirT1 catalytic activity is required for male fertility and metabolic homeostasis in miceSemantic proximity Read ↗

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.Semantic proximity Read ↗

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.Semantic proximity Read ↗

Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseasesSemantic proximity Read ↗

Caloric restriction, SIRT1 and longevitySemantic proximity Read ↗

Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular DystrophySemantic proximity Read ↗

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.Semantic proximity Read ↗

sirt1-null mice develop an autoimmune-like conditionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.