Article
SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 May 2017
Roichman Asael, Kanfi Yariv, Glazz Renana, Naiman Shoshana, Amit Uri, Landa Natalie, Tinman Simon, Stein Ilan, Pikarsky Eli, Leor Jonathan, Cohen Haim Y
Abstract excerpt
The extension in human lifespan in the last century results in a significant increase in incidence of age related diseases. It is therefore crucial to identify key factors that control elderly healthspan. Similar to dietary restriction, mice overexpressing the NAD+ dependent protein deacylase SIRT6 (MOSES) live longer and have reduced IGF-1 levels. However, it is as yet unknown whether SIRT6 also affects various...
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