Article
Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein.
Nature communications - 2 Jan 2018
Watanabe Hitoshi, Inaba Yuka, Kimura Kumi, Matsumoto Michihiro, Kaneko Shuichi, Kasuga Masato, Inoue Hiroshi
Abstract excerpt
Impaired hepatic glucose uptake (HGU) causes postprandial hyperglycemia in type 2 diabetes. Here, we show that diminished hepatic Sirt2 activity impairs HGU in obese diabetic mice. Hepatic Sirt2 overexpression increases HGU in high-fat diet (HFD)-fed obese diabetic mice and mitigates their impaired glucose tolerance. Hepatic Sirt2 knockdown in non-diabetic mice reduces HGU and causes impaired glucose tolerance....
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