Article
De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria.
Molecular biology and evolution - 1 Jul 2018
Redmond Seth N, MacInnis Bronwyn M, Bopp Selina, Bei Amy K, Ndiaye Daouda, Hartl Daniel L, Wirth Dyann F, Volkman Sarah K, Neafsey Daniel E
Abstract excerpt
Detecting de novo mutations in viral and bacterial pathogens enables researchers to reconstruct detailed networks of disease transmission and is a key technique in genomic epidemiology. However, these techniques have not yet been applied to the malaria parasite, Plasmodium falciparum, in which a larger genome, slower generation times, and a complex life cycle make them difficult to implement. Here, we demonstrate...
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