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Article

Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism.

Chemical biology & drug design - 1 Sept 2017

Lougiakis Nikolaos, Frakolaki Efseveia, Karmou Panagiota, Pouli Nicole, Marakos Panagiotis, Madan Vanesa, Bartenschlager Ralf, Vassilaki Niki

Abstract excerpt

A series of new tricyclic nucleosides were synthesized and evaluated as hepatitis C virus (HCV) replication inhibitors. Initial screening in a HCV replicon system, derived from a genotype 1b isolate, identified 9-benzylamino-3-(β-D-ribofuranosyl)-3H-imidazo[4',5':5,6]pyrido[2,3-b]pyrazine (15d) as the most potent analogue. Comparative assessment of 15d activity against HCV full-length viruses or subgenomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28245093
DOI: 10.1111/cbdd.12966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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