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Article

Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.

Antimicrobial agents and chemotherapy - 1 Jun 2012

Lam Angela M, Espiritu Christine, Bansal Shalini, Micolochick Steuer Holly M, Niu Congrong, Zennou Veronique, Keilman Meg, Zhu Yuao, Lan Shuiyun, Otto Michael J, Furman Phillip A

Abstract excerpt

PSI-7977, a prodrug of 2'-F-2'-C-methyluridine monophosphate, is the purified diastereoisomer of PSI-7851 and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. In this study, we profiled the activity of PSI-7977 and its ability to select for resistance using a number of different replicon cells. Results showed that PSI-7977 was active against genotype (GT) 1a, 1b, and 2a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22430955
DOI: 10.1128/AAC.00054-12
PMCID: PMC3370800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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