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Rap1 Stabilizes β-Catenin and Enhances β-Catenin–Dependent Transcription and Invasion in Squamous Cell Carcinoma of the Head and Neck

23 Dec 2009

Abstract excerpt

PURPOSE: In head and neck squamous cell carcinoma (HNSCC) cells, Rap1 shuttles between the nucleus and cytoplasm. Prior findings suggested that Rap1 may modulate the beta-catenin-independent Wnt pathway in some settings, but the role of Rap1 in beta-catenin-dependent Wnt signaling remains undefined. EXPERIMENTAL DESIGN AND RESULTS: We observed that beta-catenin bound to active Rap1 in vitro and Rap1 activated...

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Share to Head and Neck Cancer Studies
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PMID: 20028760
DOI: 10.1158/1078-0432.ccr-09-1122

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