Article
The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis.
PLoS genetics - 9 Sept 2010
Nishant K T, Wei Wu, Mancera Eugenio, Argueso Juan Lucas, Schlattl Andreas, Delhomme Nicolas, Ma Xin, Bustamante Carlos D, Korbel Jan O, Gu Zhenglong, Steinmetz Lars M, Alani Eric
Abstract excerpt
Accurate estimates of mutation rates provide critical information to analyze genome evolution and organism fitness. We used whole-genome DNA sequencing, pulse-field gel electrophoresis, and comparative genome hybridization to determine mutation rates in diploid vegetative and meiotic mutation accumulation lines of Saccharomyces cerevisiae. The vegetative lines underwent only mitotic divisions while the meiotic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.