Sexual back talk with evolutionary implications: stimulation of the Drosophila sex-determination gene sex-lethal by its target transformer.

doi:10.1534/genetics.108.093898

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Article

Sexual back talk with evolutionary implications: stimulation of the Drosophila sex-determination gene sex-lethal by its target transformer.

Genetics - 1 Dec 2008

Siera Scott G, Cline Thomas W

Abstract excerpt

We describe a surprising new regulatory relationship between two key genes of the Drosophila sex-determination gene hierarchy, Sex-lethal (Sxl) and transformer (tra). A positive autoregulatory feedback loop for Sxl was known to maintain somatic cell female identity by producing SXL-F protein to continually instruct the target gene transformer (tra) to make its feminizing product, TRA-F. We discovered the...

Topics

Animals
Drosophila
Drosophila Proteins
Embryo, Nonmammalian
Evolution, Molecular
Female
Genes, Insect
Gonads
Male
Mutation
Nuclear Proteins
RNA Splicing
RNA, Messenger
RNA-Binding Proteins
Sex Determination Processes

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Identifiers

PMID: 18845845
DOI: 10.1534/genetics.108.093898
PMCID: PMC2600935

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