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Article

Sexual back talk with evolutionary implications: stimulation of the Drosophila sex-determination gene sex-lethal by its target transformer.

Genetics - 1 Dec 2008

Siera Scott G, Cline Thomas W

Abstract excerpt

We describe a surprising new regulatory relationship between two key genes of the Drosophila sex-determination gene hierarchy, Sex-lethal (Sxl) and transformer (tra). A positive autoregulatory feedback loop for Sxl was known to maintain somatic cell female identity by producing SXL-F protein to continually instruct the target gene transformer (tra) to make its feminizing product, TRA-F. We discovered the...

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Identifiers

PMID: 18845845
DOI: 10.1534/genetics.108.093898
PMCID: PMC2600935

Genes

TRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sexual back talk with evolutionary implications: stimulation of the Drosophila sex-determination gene sex-lethal by its target transformer.PMID 18845845Read ↗

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Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila.Semantic proximity Read ↗

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