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Article

Functional conservation and divergence of intersex, a gene required for female differentiation in Drosophila melanogaster.

Development genes and evolution - 1 Jan 2005

Siegal Mark L, Baker Bruce S

Abstract excerpt

In Drosophila melanogaster, somatic sexual differentiation is regulated by a well characterized genetic hierarchy, by which the ratio of X chromosomes to autosomes (X:A) ultimately directs the deployment of sex-specific transcription factors encoded by doublesex (dsx) and fruitless (fru). In other dipterans, the X:A ratio is not the primary sex-determination signal. Correspondingly, the Drosophila hierarchy is...

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PMID: 15645316
DOI: 10.1007/s00427-004-0445-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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