Article
Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function.
Blood - 25 Nov 2010
Goodall Alison H, Burns Philippa, Salles Isabelle, Macaulay Iain C, Jones Chris I, Ardissino Diego, de Bono Bernard, Bray Sarah L, Deckmyn Hans, Dudbridge Frank, Fitzgerald Desmond J, Garner Stephen F, Gusnanto Arief, Koch Kerstin, Langford Cordelia, O'Connor Marie N, Rice Catherine M, Stemple Derek, Stephens Jonathan, Trip Mieke D, Zwaginga Jaap-Jan, Samani Nilesh J, Watkins Nicholas A, Maguire Patricia B, Ouwehand Willem H
Abstract excerpt
Within the healthy population, there is substantial, heritable, and interindividual variability in the platelet response. We explored whether a proportion of this variability could be accounted for by interindividual variation in gene expression. Through a correlative analysis of genome-wide platelet RNA expression data from 37 subjects representing the normal range of platelet responsiveness within a cohort of...
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