Article
APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.
The Journal of biological chemistry - 17 Dec 2004
Yu Qin, Chen Darlene, König Renate, Mariani Roberto, Unutmaz Derya, Landau Nathaniel R
Abstract excerpt
In the human genome the apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC)3 gene has expanded into a tandem array of genes termed APOBEC3A-G. Two members of this family, APOBEC3G and APOBEC3F, have been found to have potent activity against virion infectivity factor deficient (Deltavif) human immunodeficiency virus 1 (HIV-1). These enzymes become encapsidated in Deltavif HIV-1 virions and in the...
Topics
- Anti-HIV Agents
- Apolipoproteins B
- CD4-Positive T-Lymphocytes
- Catalysis
- Cell Line
- Cell Line, Tumor
- Cytidine Deaminase
- DNA, Complementary
- Gene Products, vif
- Genes, Reporter
- Genetic Vectors