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Article

Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface trafficking.

Brain research. Molecular brain research - 19 May 2004

Hughes Ethan G, Maguire Jamie L, McMinn Melanie T, Scholz Rachael E, Sutherland Margaret L

Abstract excerpt

Loss of the astrocyte-specific intermediate filament protein, glial fibrillary acidic protein (GFAP) results in an increased susceptibility to ischemic insult, enhanced hippocampal LTP, and decreased cerebellar long-term depression (LTD). Because glutamate receptor activation plays a key role in cell death and cellular plasticity responses, we wanted to determine if alterations in glial glutamate transport could...

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Source

Identifiers

PMID: 15135219
DOI: 10.1016/j.molbrainres.2004.02.021

Genes

GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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