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Article

Optimization of human immunodeficiency virus type 1 envelope glycoproteins with V1/V2 deleted, using virus evolution.

Journal of virology - 1 Jan 2009

Bontjer Ilja, Land Aafke, Eggink Dirk, Verkade Erwin, Tuin Kiki, Baldwin Chris, Pollakis Georgios, Paxton William A, Braakman Ineke, Berkhout Ben, Sanders Rogier W

Abstract excerpt

The human immunodeficiency virus type 1 envelope glycoprotein (Env) complex is the principal focus of neutralizing antibody-based vaccines. The functional Env complex is a trimer consisting of six individual subunits: three gp120 molecules and three gp41 molecules. The individual subunits have proven unsuccessful as vaccines presumably because they do not resemble the functional Env complex. Variable domains and...

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Share to Directed Molecular Evolution
Share to env Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18922866
DOI: 10.1128/JVI.01404-08
PMCID: PMC2612307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Optimization of human immunodeficiency virus type 1 envelope glycoproteins with V1/V2 deleted, using virus evolution.PMID 18922866Read ↗

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