Article
Rationally Targeted Mutations at the V1V2 Domain of the HIV-1 Envelope to Augment Virus Neutralization by Anti-V1V2 Monoclonal Antibodies.
PloS one - 1 Jan 2015
Shen Guomiao, Upadhyay Chitra, Zhang Jing, Pan Ruimin, Zolla-Pazner Susan, Kong Xiang-Peng, Hioe Catarina E
Abstract excerpt
HIV-1 envelope glycoproteins (Env) are the only viral antigens present on the virus surface and serve as the key targets for virus-neutralizing antibodies. However, HIV-1 deploys multiple strategies to shield the vulnerable sites on its Env from neutralizing antibodies. The V1V2 domain located at the apex of the HIV-1 Env spike is known to encompass highly variable loops, but V1V2 also contains immunogenic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.