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Article

An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy.

The Journal of biological chemistry - 12 Nov 2010

Orr Christopher R, Montie Heather L, Liu Yuhong, Bolzoni Elena, Jenkins Shannon C, Wilson Elizabeth M, Joseph James D, McDonnell Donald P, Merry Diane E

Abstract excerpt

Polyglutamine expansion within the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA) and is associated with misfolded and aggregated species of the mutant AR. We showed previously that nuclear localization of the mutant AR was necessary but not sufficient for SBMA. Here we show that an interdomain interaction of the AR that is central to its function within the nucleus is required for AR...

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Identifiers

PMID: 20826791
DOI: 10.1074/jbc.M110.146845
PMCID: PMC2975181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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