Article
Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance.
Molecular cell - 5 Nov 2004
He Bin, Gampe Robert T, Kole Adam J, Hnat Andrew T, Stanley Thomas B, An Gang, Stewart Eugene L, Kalman Rebecca I, Minges John T, Wilson Elizabeth M
Abstract excerpt
The androgen receptor (AR) is required for male sex development and contributes to prostate cancer cell survival. In contrast to other nuclear receptors that bind the LXXLL motifs of coactivators, the AR ligand binding domain is preferentially engaged in an interdomain interaction with the AR FXX...
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