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Article

ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor.

Nature medicine - 1 Mar 2007

Yang Zhiming, Chang Yu-Jia, Yu I-Chen, Yeh Shuyuan, Wu Cheng-Chia, Miyamoto Hiroshi, Merry Diane E, Sobue Gen, Chen Lu-Min, Chang Shu-Shi, Chang Chawnshang

Abstract excerpt

Motor neuron degeneration resulting from the aggregation of the androgen receptor with an expanded polyglutamine tract (AR-polyQ) has been linked to the development of spinal and bulbar muscular atrophy (SBMA or Kennedy disease). Here we report that adding 5-hydroxy-1,7-bis(3,4-dimethoxyphenyl)-1,4,6-heptatrien-3-one (ASC-J9) disrupts the interaction between AR and its coregulators, and also increases cell...

Topics

Androgen Receptor Antagonists
Animals
COS Cells
Cell Line
Chlorocebus aethiops
Curcumin
Disease Models, Animal
Female
Male
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscular Atrophy, Spinal

Phenotype

Receptors, Androgen

Source

Identifiers

PMID: 17334372
DOI: 10.1038/nm1547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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