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Article

ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor.

Nature medicine - 1 Mar 2007

Yang Zhiming, Chang Yu-Jia, Yu I-Chen, Yeh Shuyuan, Wu Cheng-Chia, Miyamoto Hiroshi, Merry Diane E, Sobue Gen, Chen Lu-Min, Chang Shu-Shi, Chang Chawnshang

Abstract excerpt

Motor neuron degeneration resulting from the aggregation of the androgen receptor with an expanded polyglutamine tract (AR-polyQ) has been linked to the development of spinal and bulbar muscular atrophy (SBMA or Kennedy disease). Here we report that adding 5-hydroxy-1,7-bis(3,4-dimethoxyphenyl)-1,4,6-heptatrien-3-one (ASC-J9) disrupts the interaction between AR and its coregulators, and also increases cell...

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Identifiers

PMID: 17334372
DOI: 10.1038/nm1547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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