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Article

B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy.

Journal of neuroscience research - 1 Aug 2010

Palazzolo Isabella, Nedelsky Natalia B, Askew Caitlin E, Harmison George G, Kasantsev Aleksey G, Taylor J Paul, Fischbeck Kenneth H, Pennuto Maria

Abstract excerpt

Expanded polyglutamine tracts cause neurodegeneration through a toxic gain-of-function mechanism. Generation of inclusions is a common feature of polyglutamine diseases and other protein misfolding disorders. Inclusion formation is likely to be a defensive response of the cell to the presence of unfolded protein. Recently, the compound B2 has been shown to increase inclusion formation and decrease toxicity of...

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Identifiers

PMID: 20336775
DOI: 10.1002/jnr.22389
PMCID: PMC3881232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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