B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy.

doi:10.1002/jnr.22389

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Article

B2 attenuates polyglutamine-expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy.

Journal of neuroscience research - 1 Aug 2010

Palazzolo Isabella, Nedelsky Natalia B, Askew Caitlin E, Harmison George G, Kasantsev Aleksey G, Taylor J Paul, Fischbeck Kenneth H, Pennuto Maria

Abstract excerpt

Expanded polyglutamine tracts cause neurodegeneration through a toxic gain-of-function mechanism. Generation of inclusions is a common feature of polyglutamine diseases and other protein misfolding disorders. Inclusion formation is likely to be a defensive response of the cell to the presence of unfolded protein. Recently, the compound B2 has been shown to increase inclusion formation and decrease toxicity of...

Topics

Animals
Animals, Genetically Modified
Bulbo-Spinal Atrophy, X-Linked
Cell Line
Disease Models, Animal
Drosophila melanogaster
Humans
Intracellular Space
Intranuclear Inclusion Bodies
Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neuroprotective Agents

Nitroquinolines

Peptides

Piperazines

Protein Multimerization

Rats

Receptors, Androgen

Source

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Identifiers

PMID: 20336775
DOI: 10.1002/jnr.22389
PMCID: PMC3881232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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