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Article

Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy.

Neuron - 23 Sept 2010

Nedelsky Natalia B, Pennuto Maria, Smith Rebecca B, Palazzolo Isabella, Moore Jennifer, Nie Zhiping, Neale Geoffrey, Taylor J Paul

Abstract excerpt

Spinobulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by expansion of a polyglutamine tract in the androgen receptor (AR). This mutation confers toxic function to AR through unknown mechanisms. Mutant AR toxicity requires binding of its hormone ligand, suggesting that pathogen...

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Identifiers

PMID: 20869592
DOI: 10.1016/j.neuron.2010.08.034
PMCID: PMC3514079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20869592-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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