Article
Structural and functional alterations in the androgen receptor in spinal bulbar muscular atrophy.
Biochemical Society transactions - 1 May 2001
McEwan I J
Abstract excerpt
The androgen receptor is a member of the nuclear receptor superfamily, and regulates gene expression in response to the steroid hormones testosterone and dihydrotestosterone. Mutations in the receptor have been correlated with a diverse range of clinical conditions, including androgen insensitivity, prostate cancer and spinal bulbar muscular atrophy, a neuromuscular degenerative condition. The latter is caused by...
Topics
- Animals
- Humans
- Male
- Muscular Atrophy, Spinal
- Mutation
- Peptides
- Protein Binding
- Protein Structure, Tertiary
- Receptors, Androgen
- Structure-Activity Relationship
- Trinucleotide Repeat Expansion