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Article

Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.

Molecular biology of the cell - 1 Nov 2010

Lee Hyun O, Zacharek Sima J, Xiong Yue, Duronio Robert J

Abstract excerpt

DNA synthesis-coupled proteolysis of the prereplicative complex component Cdt1 by the CRL4(Cdt2) E3 ubiquitin ligase is thought to help prevent rereplication of the genome during S phase. To directly test whether CRL4(Cdt2)-triggered destruction of Cdt1 is required for normal cell cycle progression in vivo, we expressed a mutant version of Drosophila Cdt1 (Dup), which lacks the PCNA-binding PIP box (Dup(ΔPIP))...

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Source

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Identifiers

PMID: 20826610
DOI: 10.1091/mbc.E10-02-0130
PMCID: PMC2965682

Genes

PIP
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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