Article
The Cyclin-dependent kinase inhibitor Dacapo promotes genomic stability during premeiotic S phase.
Molecular biology of the cell - 1 Apr 2009
Narbonne-Reveau Karine, Lilly Mary
Abstract excerpt
The proper execution of premeiotic S phase is essential to both the maintenance of genomic integrity and accurate chromosome segregation during the meiotic divisions. However, the regulation of premeiotic S phase remains poorly defined in metazoa. Here, we identify the p21(Cip1)/p27(Kip1)/p57(Kip2)-like cyclin-dependent kinase inhibitor (CKI) Dacapo (Dap) as a key regulator of premeiotic S phase and genomic...
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