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Article

Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease.

Journal of gastroenterology and hepatology - 1 May 2012

Hyysalo Jenni, Stojkovic Ivana, Kotronen Anna, Hakkarainen Antti, Sevastianova Ksenia, Makkonen Janne, Lundbom Nina, Rissanen Aila, Krauss Ronald M, Melander Olle, Orho-Melander Marju, Yki-Järvinen Hannele

Abstract excerpt

BACKGROUND AND AIM: A recent study in Indian subjects suggested common variants in apolipoprotein C3 (APOC3) (T-455C at rs2854116 and C-482T at rs2854117) to contribute to non-alcoholic fatty liver disease (NAFLD), plasma apoC3 and triglyceride concentrations. Our aim was to determine the contribution of genetic variation in APOC3 on liver fat content and plasma triglyceride and apoC3 concentrations in a larger...

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Source

Identifiers

PMID: 22141340
DOI: 10.1111/j.1440-1746.2011.07045.x

Genes

APOC3
PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease.PMID 22141340Read ↗

I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.Semantic proximity Read ↗

Genetic variation in the patatin-like phospholipase domain-containing protein-3 (PNPLA-3) gene in Asian Indians with nonalcoholic fatty liver disease.Semantic proximity Read ↗

<i><scp>PNPLA</scp>3</i> gene polymorphism accounts for fatty liver in community subjects without metabolic syndromeSemantic proximity Read ↗

A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population.Semantic proximity Read ↗

APOC3 rs2070666 Is Associated with the Hepatic Steatosis Independently of PNPLA3 rs738409 in Chinese Han Patients with Nonalcoholic Fatty Liver Diseases.Semantic proximity Read ↗

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.Semantic proximity Read ↗

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease.Semantic proximity Read ↗

The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.Semantic proximity Read ↗

Patatin-like phospholipase domain-containing 3 gene (PNPLA3) polymorphic (rs738409) single nucleotide polymorphisms and susceptibility to nonalcoholic fatty liver disease: A meta-analysis of twenty studies.Semantic proximity Read ↗

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.Semantic proximity Read ↗

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.Semantic proximity Read ↗

Distinct, alcohol-modulated effects of PNPLA3 genotype on progression of chronic hepatitis CSemantic proximity Read ↗

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