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Article

Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content.

International journal of obesity (2005) - 1 Jun 2012

Peter A, Kantartzis K, Machicao F, Machann J, Wagner S, Templin S, Königsrainer I, Königsrainer A, Schick F, Fritsche A, Häring H-U, Stefan N

Abstract excerpt

OBJECTIVE: It has not been solved whether subjects carrying the minor alleles of the -455T>C or -482C>T single nucleotide polymorphisms (SNPs) in the apolipoprotein-C3-gene (APOC3) have an increased risk for developing fatty liver and insulin resistance. We investigated the relationships of the SNPs with hepatic APOC3 expression and hypothesized that visceral obesity may modulate the effects of these SNPs on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21829161
DOI: 10.1038/ijo.2011.154

Genes

APOC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content.PMID 21829161Read ↗

Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease.Semantic proximity Read ↗

Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes.Semantic proximity Read ↗

Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease.Semantic proximity Read ↗

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.Semantic proximity Read ↗

Lack of effect of apolipoprotein C3 polymorphisms on indices of liver steatosis, lipid profile and insulin resistance in obese Southern Europeans.Semantic proximity Read ↗

Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects.Semantic proximity Read ↗

Apolipoprotein C3 gene polymorphisms in Southern Indian patients with nonalcoholic fatty liver disease.Semantic proximity Read ↗

PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetes.Semantic proximity Read ↗

The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver.Semantic proximity Read ↗

Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance.Semantic proximity Read ↗

Abdominal fat interacts with PNPLA3 I148M, but not with the APOC3 variant in the pathogenesis of liver steatosis in chronic hepatitis C.Semantic proximity Read ↗

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.Semantic proximity Read ↗

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